tailieunhanh - BEHAVIOR ANALYSIS in NEUROSCIENCE - PART 6

Nó đòi hỏi không có thời gian đào tạo trước và có thể được thực hiện trong một khoảng thời gian ngắn với một số lượng tương đối lớn của động vật. Ví dụ, người lớn trẻ, không bị hư hỏng (kiểm soát) chuột có thể thực hiện các phiên bản sử dụng phổ biến nhất của nhiệm vụ với mức độ tiệm cận hiệu suất đạt được trong 10-20 | and visual agnosia in AD patients also indicate the disruption of complex processes which involve both visual pathways and mnemonic 21 The MWM procedure offers a number of advantages as a means of assessing cognitive function in rodents when compared to other methods 1 It requires no pre-training period and can be accomplished in a short period of time with a relatively large number of animals. For example young adult unimpaired control rats can accomplish the most commonly employed versions of the task with asymptotic levels of performance achieved in 10 to 20 trials generally requiring no more than a few days of testing. 2 Through the use of training as well as probe or transfer trials learning as well as retrieval processes spatial bias 5 can be analyzed and compared between groups. 3 The confounding nature of olfactory trails or cues is eliminated. 4 Through the use of video tracking devices and the measure of swim speeds non-mnemonic behaviors or strategies . taxon praxis thygmotaxis etc. can be delineated and motoric or motivational deficits can be identified. 5 Visible platform tests can identify gross visual deficits that might confound interpretation of results obtained from standard MWM testing. 6 By changing the platform location both learning and re-learning experiments can be accomplished. Accordingly several doses of experimental drugs can be tested in the same group of animals. 7 While immersion into water may be somewhat unpleasant more aversive procedures such as food deprivation or exposure to electric shock are circumvented. 8 Through the use of curtains partitions etc. operation of the video tracking system by the experimenter out of sight of the test subjects also reduces distraction. 9 Finally the MWM is quite easy to set up in a relatively small laboratory is comparatively less expensive to operate than many types of behavioral tasks and is easy to master by research and technical personnel. We have found the method quite .