tailieunhanh - Báo cáo y học: "The next frontier of systems biology: higher-order and interspecies interactions"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: The next frontier of systems biology: higher-order and interspecies interactions. | Fischbach and Krogan Genome Biology 2010 11 208 http 2010 11 5 208 w Genome Biology REVIEW The next frontier of systems biology higher-order and interspeeies interactions Michael A Fischbach1 and Nevan J Krogan2 Abstract Systems approaches are not so different in essence from classical genetic and biochemical approaches and in the future may become adopted so widely that the term systems biology itself will become obsolete. Systems biology means different things to different people and one can envisage it more as a strategy for studying biological systems than as a field of biology. Systems approaches have been very successful in the realms of biochemistry and genetics especially for genetically tractable organisms and have led to a deluge of mechanistic insights into a variety of biological areas. The systematic nature of the approach involves testing or assaying all components of a biological milieu simultaneously in an unbiased fashion with no prior assumptions of what will be found. However these modern approaches are not so different when compared to more classical genetic and biochemical strategies. Finally we anticipate that the next frontier of systems biology will involve both higher-order interactions and the study of interspecies relationships in a systematic fashion. A decade ago Bruce Alberts Andrew Murray and Lee Hartwell noted that cellular components are organized into functional groups or modules and that the reductionist approach of studying each component in isolation was limiting 1 2 . Recent efforts in systems biology have taken advantage of this observation by using unbiased approaches to define the protein complexes that comprise these modules. For example two groups have used a systematic affinity tag purification and mass spectrometry approach to identify hundreds of protein Correspondence krogan@ fischbach@ Department of Bioengineering and Therapeutic Sciences and California Institute of .

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