tailieunhanh - Báo cáo y học: "Defining the chromatin signature of inducible genes in T cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Defining the chromatin signature of inducible genes in T cells. | Open Access Researc h Defining the chromatin signature of inducible genes in T cells Pek S LimH Kristine HardyH Karen L Bunting Lina Ma Kaiman Peng Xinxin Chen and Mary F Shannon Addresses Genome Biology Program and ACRF Biomolecular Resource Facility John Curtin School of Medical Research The Australian National University Garran Road Acton ACT 0200 Australia. Current address Department of Medicine Hematology-Oncology Weill Cornell Medical College 68th St New York NY 10065 USA. Current address Departments of Physiology and Pathology National Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences and School of Basic Medicine Chinese Academy of Medical Sciences and Peking Union Medical College 1 Shuaifuyuan Beijing 100730 PR China. H These authors contributed equally to this work. Correspondence Mary F Shannon. Email Published 6 October 2009 Genome Biology 2009 10 R107 doi gb-2009-l0-l0-rl 07 The electronic version of this article is the complete one and can be found online at http 2009 10 10 R107 Received 30 April 2009 Revised 27 July 2009 Accepted 6 October 2009 2009 Lim et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Specific chromatin characteristics especially the modification status of the core histone proteins are associated with active and inactive genes. There is growing evidence that genes that respond to environmental or developmental signals may possess distinct chromatin marks. Using a T cell model and both genome-wide and gene-focused approaches we examined the chromatin characteristics of genes that respond to T cell activation. Results To facilitate comparison of genes with similar basal expression levels we .