tailieunhanh - Báo cáo y học: " Simultaneous alignment of short reads against multiple genomes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Simultaneous alignment of short reads against multiple genomes. | Open Access Software Simultaneous alignment of short reads against multiple genomes Korbinian Schneeberger Jorg Hagmann Stephan Ossowski Norman Warthmann Sandra Gesing Oliver Kohlbacher and Detlef Weigel Addresses Department of Molecular Biology Max Planck Institute for Developmental Biology Spemannstrasse 37-39 D-72076 Tubingen Germany. Center for Bioinformatics Tubingen ZBIT Eberhard Karls University Tubingen Sand 14 72076 Tubingen Germany. Correspondence Detlef Weigel. Email weigel@ Published 17 September 2009 Genome Biology 2009 10 R98 doi gb-2009- 10-9-r98 The electronic version of this article is the complete one and can be found online at http 2009 10 9 R98 Received 20 July 2009 Revised 12 September 2009 Accepted l7 September 2009 2009 Schneeberger et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Genome resequencing with short reads generally relies on alignments against a single reference. GenomeMapper supports simultaneous mapping of short reads against multiple genomes by integrating related genomes . individuals of the same species into a single graph structure. It constitutes the first approach for handling multiple references and introduces representations for alignments against complex structures. Demonstrated benefits include access to polymorphisms that cannot be identified by alignments against the reference alone. Download GenomeMapper at http . Rationale Within the last few years a variety of second- or next- generation sequencing technologies have been developed to enable analyses of small to medium-sized genomes within weeks or even days. The methods are now overcoming the disadvantages of short read length currently the longest .

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