tailieunhanh - Báo cáo y học: "Joining forces in the quest for orthologs"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài:Joining forces in the quest for orthologs. | X Genome Biology Correspondence Joining forces in the quest for orthologs Toni Gabaldón Christophe Dessimoz Julie Huxley-Jones Albert J Vilella Erik LL Sonnhammer and Suzanna Lewis Addresses Bioinformatics and Genomics Programme Centre for Genomic Regulacion CRG Dr. Aiguader 88. 0800 Barcelona Spain. tETH Zurich and Swiss Institute of Bioinformatics 8092 Zurich Switzerland. Computational Biology GlaxoSmithKline Pharmaceuticals Gunnels Wood Road Stevenage Hertfordshire SG1 2NY UK. European Bioinformatics Institute Wellcome Trust Genome Campus Hinxton Cambridge CB10 1SD UK. Stockholm Bioinformatics Centre AlbaNova University Centre Stockholm University S-106 91 Stockholm Sweden. Lawrence Berkeley National Laboratory 1 Cyclotron Road 64R0121 Berkeley CA 94618 USA. Correspondence Toni Gabaldón. Email tgabaldon@ Abstract Better orthology-prediction resources would be beneficial for the whole biological community. A recent meeting discussed how to coordinate and leverage current efforts. Identifying evolutionarily related genes that is homologs is crucial for understanding the nature of genomic diversity and the routes by which it arises. Further distinguishing homologs into two types either orthologs genes derived from a common ancestor through speciation or paralogs those derived through a duplication event has important implications in studying the evolutionary processes that have shaped a given biological system and since gene duplication is often associated with processes of functional divergence for inferring the function of related genes. Indeed many common research processes depend on accurate orthology predictions such as finding the gene in a model organism corresponding to a human disease gene inferring the function of a newly sequenced gene using available experimental assays from its orthologs inferring species phylogenies by tracing the evolution of orthologous groups or the characterization of newly sequenced genomes in terms of their encoded genes.