tailieunhanh - Báo cáo y học: " An issue to remember"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: An issue to remember. | X Genome Biology Comment An issue to remember Gregory A Petsko Address Rosenstiel Basic Medical Sciences Research Center Brandeis University Waltham MA 02454-9110 USA. Email petsko@ Even by that journal s lofty and frequently self-proclaimed standards the 3 September 2009 issue of Nature is likely to be regarded as one of the most memorable in years. Many issues of a general journal have at least one thing in them that is of interest to each reader but in this case it could be argued that almost everything in this issue is likely to be of interest to practically everybody. Anyone wishing to present evidence of the health of the global scientific enterprise could probably just hold up a copy and then sit down. Nanotechnology is a field that has sometimes been characterized by more hype than results but the paper from Nadrian Seeman s lab on page 74 is worthy of all the attention it is likely to attract. It reports the design and synthesis of a triangle of three DNA helices that selfassembles into a three-dimensional periodic array. The authors then prove that the array has the intended structure by crystallizing it and determining its atomic arrangement at 4 Ả resolution. As far as I know this is the first time a well-ordered macromolecular three-dimensional crystalline lattice has been designed and successfully assembled. It opens up the possibility of manufacturing a wealth of nanoscale objects from the stuff that make up the genome including templates on which other nanoparticles can be assembled. A disclaimer is in order here Ned Seeman who is one of the pioneers of biomaterials nanotechnology has been one of my closest friends for 35 years. I remember when he first described his plans to do this project over 25 years ago so this paper is the culmination of more than two decades of effort. But he needs no special favors from me to publicize this work it is a landmark achievement and if you read nothing else in the article you should read the last .

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