tailieunhanh - Báo cáo y học: "Synorth: exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomes."

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Synorth: exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomes. | Open Access Software Synorth exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomes Xianjun Dong David Fredman and Boris Lenhard Addresses Computational Biology Unit Bergen Center for Computational Science University of Bergen Thormohlensgate 55 N-5008 Bergen Norway. tSars Centre for Marine Molecular Biology University of Bergen Thormohlensgate 55 N-5008 Bergen Norway. Current address Department for Molecular Evolution and Development Centre for Organismal Systems Biology Faculty of Life Sciences University of Vienna Althanstrasse 1090 Wien Austria. Correspondence Boris Lenhard. Email Published 21 August 2009 Genome Biology 2009 10 R86 doi gb-2009- l0-8-r86 The electronic version of this article is the complete one and can be found online at http 2009 10 8 R86 Received 29 March 2009 Revised 22 June 2009 Accepted 2l August 2009 2009 Dong et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited Abstract Genomic regulatory blocks are chromosomal regions spanned by long clusters of highly conserved noncoding elements devoted to long-range regulation of developmental genes often immobilizing other unrelated genes into long-lasting syntenic arrangements. Synorth http is a web resource for exploring and categorizing the syntenic relationships in genomic regulatory blocks across multiple genomes tracing their evolutionary fate after teleost whole genome duplication at the level of genomic regulatory block loci individual genes and their phylogenetic context. Rationale A genomic regulatory block GRB is a chromosomal region spanned by an array of highly conserved noncoding elements HCNEs for other names of these elements see