tailieunhanh - Báo cáo y học: "Candida albicans genome sequence: a platform for genomics in the absence of genetics"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Candida albicans genome sequence: a platform for genomics in the absence of genetics. | Minireview Candida albicans genome sequence a platform for genomics in the absence of genetics Frank C Odds Alistair JP Brown and Neil AR Gow Address Aberdeen Fungal Group Institute of Medical Sciences Aberdeen AB25 2ZD UK. Correspondence Frank C Odds. E-mail Published II June 2004 Genome Biology 2004 5 230 The electronic version of this article is the complete one and can be found online at http 2004 5 7 230 2004 BioMed Central Ltd Abstract Publication of the complete diploid genome sequence of the yeast Candida albicans will accelerate research into the pathogenesis of Candida infections. Comparative genomic analysis highlights genes that may contribute to C. albicans survival and its fitness as a human commensal and pathogen. For several years investigators studying the pathogenic yeast Candida albicans have had internet access to partial genomic sequence information as the Stanford DNA Sequencing and Technology Center generously released data at several stages during their sequencing project 1 . The publication of the full diploid sequence of this fungus 2 represents a landmark in the history of Candida research and is the culmination of more than ten years of work. The drive for the C. albicans genome sequence originated at the University of Minnesota with the early interest of Stewart Scherer and Paul T. Magee in the molecular genetics of C. albicans 3 the sequencing itself is the product of the Stanford Genome Technology Center headed by Ron Davis. Davis and his team have succeeded in overcoming considerable computational hurdles to eliminate the problems of aligning sequence contigs for an organism with no known haploid state. Heterozygosity at numerous alleles originally resulted in single-copy genes being assigned to two distinct contigs. The now-completed diploid genome sequence known as Assembly 19 is the result of novel alignment methods that make use of physical mapping data paired plasmid clone sequences and .