tailieunhanh - Báo cáo y học: "START lipid/sterol-binding domains are amplified in plants and are predominantly associated with homeodomain transcription factors"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: START lipid/sterol-binding domains are amplified in plants and are predominantly associated with homeodomain transcription factors. | Research Open Access START lipid sterol-binding domains are amplified in plants and are predominantly associated with homeodomain transcription factors Kathrin Schrick Diana Nguyen Wojciech M Karlowskh and Klaus FX Mayer Addresses Keck Graduate Institute of Applied Life Sciences 535 Watson Drive Claremont CA 91711 USA. Munich Information Center for Protein Sequences Institute for Bioinformatics GSF National Research Center for Environment and Health Ingolstadter Landstrasse 1 85764 Neuherberg Germany. Correspondence Kathrin Schrick. E-mail Kathrin_Schrick@ Published 27 May 2004 Genome Biology 2004 5 R41 The electronic version of this article is the complete one and can be found online at http 2004 5 6 R41 Received 27 January 2004 Revised 8 April 2004 Accepted 30 April 2004 2004 Schrick et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background In animals steroid hormones regulate gene expression by binding to nuclear receptors. Plants lack genes for nuclear receptors yet genetic evidence from Arabidopsis suggests developmental roles for lipids sterols analogous to those in animals. In contrast to nuclear receptors the lipid sterol-binding StAR-related lipid transfer START protein domains are conserved making them candidates for involvement in both animal and plant lipid sterol signal transduction. Results We surveyed putative START domains from the genomes of Arabidopsis rice animals protists and bacteria. START domains are more common in plants than in animals and in plants are primarily found within homeodomain HD transcription factors. The largest subfamily of HD-START proteins is characterized by an HD amino-terminal to a plant-specific leucine zipper with an internal loop whereas in a smaller subfamily the HD precedes a classic leucine zipper.