tailieunhanh - Báo cáo y học: "Panmixia postponed: ancestry-related assortative mating in contemporary human populations"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Panmixia postponed: ancestry-related assortative mating in contemporary human populations. | X Genome Biology Minireview Panmixia postponed ancestry-related assortative mating in contemporary human populations Andrew S Burrell and Todd R Disotell Address Center for the Study of Human Origins Department of Anthropology New York University 25 Waverly Place New York NY 10003 USA. Correspondence Todd Disotell. Email Abstract A study of two different populations reveals that in both the choice of a spouse is non-random not only in respect of broad ethnic group but also in regard to specific ancestries within that group. The cause of this surprising bias remains unclear. The past 500 years have been characterized by unprecedented episodes of human migration and admixture particularly in the Americas. Technological innovations have to a certain extent reduced the impact of geography on human behavior raising the possibility of a truly global population. At a local level however geographic demographic linguistic cultural and even legal barriers now and in the past limit and circumscribe human mate choices. For example cultural biases towards patrilocal or matrilocal marriage where the married couple set up home in the place of origin of the man or woman respectively can lead to the differential structuring of male or female genetic variation 1 . Caste systems can similarly lead to the stratification of genetic structure within societies 2 . The patterns of divergence and admixture that characterize human populations are the result of complex cultural and evolutionary processes but can also negatively influence the outcomes of biomedical studies associating disease susceptibilities and other biomedical traits with particular genes 3 . In this context a paper by Risch et al. 4 in Genome Biology is especially interesting in that they used ancestry informative markers AIMs to document the genetic signature of assortative mating in contemporary human populations. These genetic markers document the contribution of particular ancestral groups to an