tailieunhanh - The changing face of genomics

30 April 2004 Genome Biology 2004, 5:324 The electronic version of this article is the complete one and can be found online at © 2004 BioMed Central Ltd reviews A report on the 5th annual Advances in Genome Biology and Technology (AGBT) and Automation in DNA Mapping and Sequencing (AMS) meeting, Marco Island, USA, 4-7 February 2004. The annual meeting on Advances in Genome Biology and Technology was very different this year - in contrast to previous years, only a handful of talks covered the latest large-scale sequencing projects and the next species to be sequenced. This meeting took for granted. | Meeting report The changing face of genomics Manolis Kellis Address The Broad Institute Massachusetts Institute of Technology and Harvard University Cambridge MA 02138 and Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology Cambridge MA 02139 USA. E-mail manoli@ Published 30 April 2004 Genome Biology 2004 5 324 The electronic version of this article is the complete one and can be found online at http 2004 5 5 324 2004 BioMed Central Ltd A report on the 5th annual Advances in Genome Biology and Technology AGBT and Automation in DNA Mapping and Sequencing AMS meeting Marco Island USA 4-7 February 2004. The annual meeting on Advances in Genome Biology and Technology was very different this year - in contrast to previous years only a handful of talks covered the latest large-scale sequencing projects and the next species to be sequenced. This meeting took for granted that we can sequence assemble and align complete genomes - achievements that only a few years ago seemed daunting if not unthinkable. The focus of the meeting has instead shifted towards the new challenges in genomics particularly in the areas of gene regulation cell dynamics and genome evolution. Cell regulation and organism development Given the primary sequence of a species a major goal of current genomics efforts is to understand the regulatory mechanisms and control circuitry of the cell. Towards this goal Rick Young Massachusetts Institute of Technology and Whitehead Institute Cambridge USA presented the completion of the yeast protein-DNA interaction map. Using chromatin immuno-precipitation ChIP technology in combination with microarray chips containing all intergenic regions his group has undertaken a genome-wide study of the targets of all the roughly 200 transcriptional regulators in yeast under multiple environmental conditions. They characterized the sequence-specificity of these regulators using numerous motif-discovery tools