tailieunhanh - The mechanism of prion strain propagation

Studies of mammalian prion diseases such as bovine spongiform encephalopathy have suggested that different strains consist of prion proteins with different conformations. Two recent studies of yeast prions have now formally demonstrated that multiple stable protein conformations are the basis of strain variation. deposited research Transmissible spongiform encephalopathies (TSEs) are a group of closely related neurodegenerative conditions of animals | Minireview The mechanism of prion strain propagation Glenn C Telling Address Sanders Brown Center on Aging Department of Microbiology Immunology and Molecular Genetics Department of Neurology and PhD Program in Gerontology University of Kentucky Lexington KY 40536 USA. E-mail gtell2@ Published 22 April 2004 Genome Biology 2004 5 222 The electronic version of this article is the complete one and can be found online at http 2004 5 5 222 2004 BioMed Central Ltd Abstract Studies of mammalian prion diseases such as bovine spongiform encephalopathy have suggested that different strains consist of prion proteins with different conformations. Two recent studies of yeast prions have now formally demonstrated that multiple stable protein conformations are the basis of strain variation. Transmissible spongiform encephalopathies TSEs are a group of closely related neurodegenerative conditions of animals and humans that includes sheep scrapie chronic wasting disease of deer and elk bovine spongiform encephalopathy BSE and human Creutzfeldt-Jakob disease CJD . TSEs attracted interest and considerable controversy well before the epidemic of BSE and the subsequent appearance of a new variant of human CJD because of their extraordinary features. It was once widely believed that TSEs were caused by infectious agents containing a nucleic-acid genome but the prevailing view now attributes these diseases to subcellular pathogens called prions which are defined as small proteinaceous infectious particles that lack informational nucleic acid 1 . Although the precise molecular structure of the infectious agent has still not been definitively identified considerable evidence supports the unorthodox hypothesis that prions are composed largely if not entirely of a pathogenic conformation of the prion protein PrP referred to as PrPSc and that during the disease process PrPSc imposes its conformation on the normal host-encoded version of PrP PrPC resulting in the .

• Báo cáo khoa học
• biology
• biological research
• applied biology
• modern biology
• biological engineering research
• metazoan systems
• High Yield cell and molecular biology
• Cell and molecular biology
• The cell cycle
• Molecular biology of cancer
• Cell biology of the immune system
• Molecular biology techniques
• Identification of human disease genes
• Campbell biology
• Lecture Campbell biology
• Biological sciences
• Systems biology
• Molecular biology
• Molecular biology of the gene
• Study of biology
• Exploring life
• Lecture Biology
• Foundations of modern biology
• Branches of biology
• The term biology is derived from
• Although biology in its modern
• form is a relatively recent development
• sciences related to and included
• educators
• medical profession
• micro biology ebook
• physiology ebook
• micro biology document
• micro biology specific study
• micro biology research
• the taxonomist
• biology dictionary
• English term biological
• biological materials
• biology textbooks
• biology lecture
• Lecture AP Biology
• Biological organization
• Conservation biology
• Global change
• Cancer systems biology
• Network biology
• Gene expression profiles
• Cancer signaling maps
• The biodiversity crisis
• Ebook Modern Biology
• Foundations of biology
• Cell biology
• Human genetics
• Inheritance patterns
• Cellular reproduction
• Cellular respiration
• từ điển sinh học
• biology life science
• life science test
• biology life science standards vocabulary
• sinh học
• Levels of biological organization
• Campbells Biology
• Restoration ecology
• General inh school
• General biology curriculum
• lectures of general biology
• General biological materials
• outlines of general biology
• the theory of general biology
• francis walters
• physiolog
• secondary Schools