tailieunhanh - Báo cáo khoa học: "Epigallocatechin-3 gallate prevents cardiac hypertrophy induced by pressure overload in rats"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Epigallocatechin-3 gallate prevents cardiac hypertrophy induced by pressure overload in rats | J. Vet. Set. 2007 8 2 121-129 JOURNAL OF Veterinary Science Epigallocatechin-3 gallate prevents cardiac hypertrophy induced by pressure overload in rats Jia Hao1 Chan-Hyung Kim1 Tae-Sun Ha2 Hee-Yul Ahn1 1 Department ofPharmacology and2Department of Pediatrics College of Medicine Chungbuk National University Cheongju 361763 Korea Pressure overload diseases such as valvular stenosis and systemic hypertension manifest morphologically in patients as cardiac concentric hypertrophy. Prevention of cardiac remodeling due to increased pressure overload is important to reduce morbidity and mortality. Epigallocatechin-3 gallate EGCG is a major bioactive polyphenol present in green tea which has been found to be a nitric oxide-mediated vasorelaxant and to be cardioprotective in myocardial ischemia-reperfusion injury. Therefore we investigated whether EGCG supplementation could reduce in vivo pressure overload-mediated cardiac hypertrophy. Cardiac hypertrophy was induced by suprarenal transverse abdominal aortic constriction AC in rats. Three weeks after AC surgery heart to body weight ratio increased in the AC group by 34 compared to the sham group. EGCG administration suppressed the load-induced increase in heart weight by 69 . Attenuation of cardiac hypertrophy by EGCG was associated with attenuation of the increase in myocyte cell size and fibrosis induced by aortic constriction. Despite abolition of hypertrophy by EGCG transstenotic pressure gradients did not change. Echocardiogram revealed that increased left ventricular systolic dimensions and deteriorated systolic function were relieved by EGCG These results suggest that EGCG prevents the development of left ventricular concentric hypertrophy by pressure overload and may be a useful therapeutic modality to prevent cardiac remodeling in patients with pressure overload myocardial diseases. Key words cardiac hypertrophy EGCQ pressure overload Introduction Increased cardiovascular mortality is a serious problem in modem .