tailieunhanh - Design for the Environment Program Alternatives Assessment Criteria for Hazard Evaluation

Some studies are content with establishing simple correlations, while others involve sophisticated econometric analysis, attempting to ascertain the existence and direction of causality. Yet other studies involve complex systems with feedback loops or large simulation models with scenario analysis. Inevitably, they reach different conclusions even when they analyze the same body of data because of differences in perspectives, levels of aggregation and methods of analysis. Another critical difference is the degree to which the studies take into account the relevant context and which intervening, mediating or interacting variables have been included in the analysis. . | Design for the Environment Program Alternatives Assessment Criteria for Hazard Evaluation Version August 2011 Office of Pollution Prevention Toxics . Environmental Protection Agency . EPA Design for the Environment Program Alternatives Assessment Criteria for Hazard Evaluation Version August 2011 To ensure that the Alternatives Assessment Criteria for Hazard Evaluation remain relevant and useful for distinguishing among chemicals DfE may update the criteria based on experience conducting alternatives assessments and on stakeholder input. Additional developments likely to prompt criteria review reevaluation and possible revision include changes to the Globally Harmonized System GHS or EPA programmatic criteria which are integral to the Alternatives Assessment Criteria as well as advances in science such as those relating to endpoint characterization or testing methodologies. - 1 - . EPA Design for the Environment Program Alternatives Assessment Criteria for Hazard Evaluation Version August 2011 Table of Contents 1. 4 2. General 5 3. 6 4. Toxicological Criteria . - 10 . Human Health Effects . - 11 Acute Mammalian Toxicity . - 11 Carcinogenicity. - 12 Mutagenicity Genotoxicity . - 13 Reproductive and Developmental Toxicity including Developmental Neurotoxicity . - 14 Neurotoxicity . - 16 Repeated Dose 17 Respiratory and Skin 18 Eye and Skin Irritation 20 Endocrine 21 . Environmental Toxicity and Fate . - 22 Aquatic Toxicity. - 22 Environmental Persistence . - 23 Bioaccumulation . - 24 5. Additional Endpoints. - 25 6. Designating Hazard Using Authoritative Lists. - 27 Acute Mammalian 27 Carcinogenicity. - 28 Mutagenicity Genotoxicity . - 29 Reproductive and Developmental Toxicity. - 29 Repeated Dose 30 Respiratory and Skin Sensitization.

• Môi trường
• Chemotaxonomic Study
• Quinone Compounds
• Heartwood
• Javanese Teak
• Using GC MS
• Gas Chromatographic
• Compounds in Field Peas
• Chemotaxonomic
• Study Based