tailieunhanh - Expert Systems for Human Materials and Automation Part 2

Tham khảo tài liệu 'expert systems for human materials and automation part 2', kỹ thuật - công nghệ, cơ khí - chế tạo máy phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | SeDeM Diagram A New Expert System for the Formulation of Drugs in Solid Form 21 Carr Index limits are based on references in Tecnologia Farmaceutica by S. Casadio Casadio 1972 and on monograph of Ph Eur Ph Eur 2011 . Icd. The limit is determined empirically from compression tests on many powdered substances based on the maximum hardness obtained without producing capped or broken tablets. This hardness is then established as the maximum limit. The minimum value is 0 . This value implies that no tablets are obtained when the powders are compressed. IH Powder flow repose angle. The limits are set on the basis of the monographs described in Handbook of Pharmaceutical Excipients Kibbe 2006 and monograph of Ph Eur Ph Eur 2011 or other references in Tecnologia Farmaceutica by S. Casadio Casadio 1972 . HR. The limits are established on the basis of the references cited elsewhere such as Farmacotecnia teórica y práctica by José Helman Helman 1981 . The optimum humidity is between 1 to 3 . Hygroscopicity is based on the Handbook of Pharmaceutical Excipients Kibbe 2006 based on manitol not hygroscopic and sorbitol highly hygroscopic . Particle size. The limits are based on the literature. These sources Kibbe 2006 report that rheological and compression problems occur when the percentage of fine particles in the formulation exceeds 25 . The limits for the Homogeneity Index I0 are based on the distribution of the particles of the powder see Table 3 indicating the size of the sieve in mm average particle size in each fraction and the difference in average particle size in the fraction between and and the others . A value of 5 on a scale from 0 to 10 was defined as the minimum acceptable value MAV as follows Sieve mm Corresponding fraction Average of the diameter of the fraction Corresponding diameter dm . dm n Dif dm with the mayor component 0 355 - 0 500 Fm 2 427 dm 2 271 0 212 - 0 355 Fm 1 283 dm 1 127 0 100 - 0 212 Fm 156 dm 0 0 050 -0 100 Fm-1 75 .

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