tailieunhanh - Báo cáo sinh học: " Backsolving in combined-merit models for marker-assisted best linear unbiased prediction of total additive genetic merit"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Backsolving in combined-merit models for marker-assisted best linear unbiased prediction of total additive genetic merit | 611 Genet Sei Evol 1996 28 611-616 @ Elsevier Inra Note Backsolving in combined-merit models for marker-assisted best linear unbiased prediction of total additive genetic merit s Saito1 H Iwaisaki1 2 1 Graduate School of Science and Technology 2Department of Animal Science Faculty of Agriculture Niigata University Niigata 950-21 Japan Received 6 May 1997 accepted 12 August 1997 Summary - The procedures for backsolving are described for combined-merit models for marker-assisted best linear unbiased prediction or for the animal and the reduced animal models which contain fixed effects and random effects of total additive genetic merits and residuals. Using the best linear unbiased predictors BLƯP of the total additive genetic merits and the residuals with the present procedures the BLUP of additive genetic effects due to quantitative trait loci QTLs unlinked to the marker locus and additive effects due to the marked QTL are also obtained. These backsolutions are identical to the solutions in the Fernando and Grossman animal model. best linear unbiased prediction marker-assisted selection combined-merit model backsolving additive effect of marked QTL alleles Resume Restitution des solutions pour la valeur génétique additive totale en cas de prediction BLUP utilisant des marqueurs. On deceit la procedure de restitution des solutions completes pour la valeur génétique totale à partir des solutions d un modèle animal réduit. On peut obtenir également des solutions completes pour les effets génétiques additifs lies à un QTL marque et les effets lies aux autres genes. Ces solutions sont identiques à celles du modèle animal de Fernando et Grossman. meilleure prediction linéaire non biaisée selection assistée par marqueur restitution des solutions QTL marques INTRODUCTION In recent years a large number of genetic polymorphisms for example restricted fragment length polymorphisms eg Botstein et al 1980 variable numbers of tandem repeats eg Jeffreys et al 1985 Nakamura et al .