tailieunhanh - Báo cáo khoa hoc:"Heritability of susceptibility to Salmonella enteritidis infection in fowls and test of the role of the chromosome carrying the NRAMP1 gene"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Heritability of susceptibility to Salmonella enteritidis infection in fowls and test of the role of the chromosome carrying the NRAMP1 gene | 211 Genet. Sel. Evol. 34 2002 211-219 INRA EDP Sciences 2002 DOI gse 2002004 Original article Heritability of susceptibility to Salmonella enteritidis infection in fowls and test of the role of the chromosome carrying the NRAMP1 gene Odile Girard-Santosuosso Frédéric LANTIERa Isabelle LANTiERa Nat BUMSTEADb Jean-Michel Elsenc Catherine BEAUMONTd a Département de santé animale Station de pathologie infectieuse et immunologie Institut national de la recherche agronomique 37380 Nouzilly France b Compton laboratory Institute for Animal Health Compton Newbury Berkshire BBSRC G20 7NN UK c Département de génétique animale Station d amélioration génétique des animaux Institut national de la recherche agronomique 31326 Castanet-Tolosan France d Département de génétique animale Station de recherches avicoles Institut national de la recherche agronomique 37380 Nouzilly France Received 15 March 2001 accepted 5 November 2001 Abstract - 373 thirteen-week-old chicks issued from a commercial cross and 312 chickens from the L2 line were intravenously inoculated with 106 Salmonella enteritidis and the numbers of Salmonella in the spleen liver and genital organs were assessed 3 days later. Heritabilities of the number of Salmonella were estimated at and in the liver and in the spleen and at and in the genital organs in the first and second experiments respectively. The difference between the two experiments could result from sampling variations and from differences in the genetic structure of the two populations possibly including both heterosis and additive effects as well as their interaction in the first experiment. Genetic correlations between the number of bacteria in the genital organs and liver and in the first and second experiments respectively and spleen and were positive. Moreover a significant within-sire effect of VIL1 a marker gene for NRAMP1 was observed in 117