tailieunhanh - Báo cáo khoa học: " Immunosuppression by T regulatory cells in cows infected with Staphylococcal superantigen"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Immunosuppression by T regulatory cells in cows infected with Staphylococcal superantigen | J. Vet. Set. 2005 6 3 247-250 JOURNAL OF Short communication Veterinary Science Immunosuppression by T regulatory cells in cows infected with Staphylococcal superantigen Byoung Sun Chang1 6 Gregory A. Bohach2 Sang-Un Lee3 William c. Davis4 Lawrence K Fox5 Witold A. Ferens2 Keun Seok Seo2 Hye Cheong Koo6 Nam Hoon Kwon6 Yong Ho Park6 AnimalHealth Research LG Life Sciences Ltd. Daejeon 305-380 Korea 2Department of Microbiology Molecular Biology and Biochemistry University of Idaho Moscow ID 83844 USA department of Immunology The Scripps Research Institute IMM-32 10550 North Torrey Pines Road La Jolla CA 92037 USA Department of Veterinary Microbiology and Pathology and5Department of Veterinary Clinical Sciences College of Veterinary Medicine Washington State University Pullman WA 99164 USA department of Microbiology College of Veterinary Medicine and School of Agricultural Biotechnology Seoul National University Seoul 151-742 Korea Our recent study has provided that the in vitro SECinduced proliferation of bovine T cells is preceded by a period of a non-pi olifci ativc immunoregulation of T cells that may be associated with cytokine production regulated by type 1 or type 2 T cells. Inversion of CD4 CI 8 T cell ratio and induction of CD8 T cells with immunoregulatory activity could increase the probability of intracellular survival of Staphylococcus aureus S. aureus . The increase of activated CD8 ACT2 B0CD8 T cells in cows with mastitis caused by A. aureus may be associated with immune-regulatory function in the bovine mammary gland. The difference and similarity between bovine activated CD8 T cells CD8 CD26 and well-established human c 1 4 c 1 25 T regulatory Tr cells may help to reveal their unique immune regulatory system in the host infected with A. aureus. Key words bovine mastitis CD4 CD25 T regulatory cells immunosuppression Staphylococcus aureus superantigens Early studies on bovine mononuclear leukocyte subpopulations in peripheral blood PBL and mammary gland