tailieunhanh - Báo cáo khoa học: "Ketamine anaesthesia following premedication of rabbits with vitamin C"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Ketamine anaesthesia following premedication of rabbits with vitamin C | J. Vet. Sci. 2005 6 3 239-241 JOURNAL OF Veterinary Science Ketamine anaesthesia following premedication of rabbits with vitamin c Abdullahi Elsa Stephen Ubandawaki Department of Veterinary Medicine and Surgery Usmanu Danfodiyo University Sokoto Nigeria The effects of vitamin c on ketamine anesthesia was studied. In normal rabbits the onset and duration of ketamine induced anesthesia were and min respectively. Pre-treatment of rabbits with 30 60 and 240 mg kg . of vitamin c followed by ketamine 40 mg kg . resulted in significant p decrease in the onset and increase in duration of ketamine anesthesia to and and and min respectively. There was also significant p decrease in the heart rates in the animals treated with vitamin c and ketamine combinations. Serum analysis showed a significant p increase in blood glucose. The observed decreased in serum calcium and phosphorous following ketamine injection was prevented by pretreatment with vitamin c. These results suggest that vitamin c at higher doses could potentiate ketamine anesthesia in rabbits. Key words ketamine rabbits vitamin c Introduction Vitamin c possesses properties that exert modulating influence on the central nervous system either physiologically or pharmacologically. It is believed that vitamin c is an important regulator of mood and behaviours from reports of observed symptoms of insomnia and anxiety 11 12 . High amount of vitamin c probably has similar physiological properties as amphetamine in the central nervous system. Depression and impairment of nervous system functions have been reported due to deficiency of this water-soluble vitamin 10 13 . In spite of several studies the actual physiological role of vitamin c in the normal function of central nervous systems remains unclear though it is known to be highly concentrated in the brain 11 High doses of vitamin c have been reported to induce sleep disturbances