tailieunhanh - Báo cáo khoa hoc:" A method to optimize selection on multiple identified quantitative trait loci"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: A method to optimize selection on multiple identified quantitative trait loci | Genet. Sel. Evol. 34 2002 145-170 145 INRA EDP Sciences 2002 DOI gse 2002001 Original article A method to optimize selection on multiple identified quantitative trait loci Reena CHAKRABORTYa Laurence MOREAUb Jack . DEKKERSa a Department of Animal Science 225C Kildee Hall Iowa State University Ames IA 50011 USA b Inra-UPS-Ina pg Station de génétique végétale Ferme du Moulon 91190 Gif-sur-Yvette France Received 5 February 2001 accepted 15 October 2001 Abstract - A mathematical approach was developed to model and optimize selection on multiple known quantitative trait loci QTL and polygenic estimated breeding values in order to maximize a weighted sum of responses to selection over multiple generations. The model allows for linkage between QTL with multiple alleles and arbitrary genetic effects including dominance epistasis and gametic imprinting. Gametic phase disequilibrium between the QTL and between the QTL and polygenes is modeled but polygenic variance is assumed constant. Breeding programs with discrete generations differential selection of males and females and random mating of selected parents are modeled. Polygenic EBV obtained from best linear unbiased prediction models can be accommodated. The problem was formulated as a multiplestage optimal control problem and an iterative approach was developed for its solution. The method can be used to develop and evaluate optimal strategies for selection on multiple QTL for a wide range of situations and genetic models. selection quantitative trait loci optimization marker assisted selection 1. INTRODUCTION In the past decades several genes with substantial effects on quantitative traits have been identified facilitated by developments in molecular genetics. Prime examples in pigs are the ryanodine receptor gene for stress susceptibility and meat quality 8 and the estrogen receptor gene for litter size 17 . Parallel efforts in the search for genes that affect quantitative traits have focused on the .

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