tailieunhanh - Báo cáo khoa học: "Human embryonic stem cells and therapeutic cloning"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Human embryonic stem cells and therapeutic cloning | J. Vet. Sci. 2005 6 2 87-96 JOURNAL OF Review Veterinary Science Human embryonic stem cells and therapeutic cloning Woo Suk Hwan 5 Byeong Chun Lee12 Chang Kyu Lee3 Sung Keun Kang1 2 Department of Theriogenology and Biotechnology College of Veterinary Medicine Seoul National University Seoul 151-742 Korea 2The Xenotransplantation Research Center Seoul National University Hospital Seoul 110-744 Korea School of Agricultural Biotechnology Seoul National University Seoul 151-742 Korea The remarkable potential of embryonic stem ES cells is their ability to develop into many different cell types. ES cells make it possible to treat patients by transplanting specialized healthy cells derived from them to repair damaged and diseased cells or tissues known as stem cell therapy . However the issue of immunocompatibility is one of considerable significance in ES cell transplantation. One approach to overcome transplant rejection of human ES hES cells is to derive hES cells from nuclear transfer of the patient s own cells. This concept is known as therapeutic cloning . In this review we describe the derivations of ES cells and cloned ES cells by somatic cell nuclear transfer and their potential applications in transplantation medicine. Key words embryonic stem cell somatic cell nuclear transfer stem cell pluripotency Introduction Stem cells can replicate themselves and generate into more specialized cell types as they multiply. There are two kinds of stem cells in the body originated from embryonic or adult tissues. Adult stem cells are undifferentiated cells found among differentiated cells in a tissue or organ. They can renew themselves and can differentiate to yield the major specialized cell types of the tissue or organ. Embryonic stem ES cells are derived from a blastocyst that is developed from in vitro fertilized egg. The remarkable potential of stem cells is their ability to develop into many different cell types which serves as a sort of repair system for the body. Stem