tailieunhanh - Báo cáo khoa học: " Exposure to genistein does not adversely affect the reproductive system in adult male mice adapted to a soy-based commercial diet"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Exposure to genistein does not adversely affect the reproductive system in adult male mice adapted to a soy-based commercial diet | J. Vet. Sci. 2004 5 3 227-234 JOURNAL OF Veterinary Science Exposure to genistein does not adversely affect the reproductive system in adult male mice adapted to a soy-based commercial diet Beom Jun Lee1 Jong-Koo Kang1 Eun-Yong Jung1 Young Won Yun1 In-Jeoung Baek1 Jung-Min Yon1 Yoon-Bok Lee2 Heon-Soo Sohn2 Jae-Yong Lee3 Kang-Sung Kim4 Sang-Yoon Nam1 1 Department of Veterinary Medicine and Research Institute of Veterinary Medicine Chungbuk National University Cheongju 361-763 Korea Central Research Institute Dr. Chungs Food Co. Ltd. Cheongju 360-290 Korea 3Department of Biochemistry College of Medicine Hallym University Chunchon 200-702 Korea Department of Food Science and Nutrition Yong In University Yongin 449-714 Korea Genistein a soybean-originated isoflavone is widely consumed by humans for putative beneficial health effects but its estrogenic activity may affect adversely the development of male reproductive system. Five-week-old ICR mice were purchased and fed with a soybean-based Purina Chow diet until 6 months of age. The animals were exposed by gavage to genistein mg kg day or 170-estradiol gg kg day for five weeks. Corn oil was used for the negative control. The animals were fed the caseinbased AIN-76A diet throughout the experimental periods. There were no significant differences in body and organ weights of mice among experimental groups. No significant differences in sperm counts and sperm motile characteristics were found between the control and the genistein groups. Treatment of 170-estradiol caused a significant decrease in epididymal sperm counts compared to the control p . The level of phospholipid hydroxide glutathione peroxidase in the epididymis of mice exposed to genistein was significantly higher than that of the control mice p . 170-estradiol treatment caused a reduction of germ cells in the testis and hyperplasia of mucosal fold region in the prostate of mice. Genistein treatment did not cause any lesion in the testis .