tailieunhanh - Báo cáo khoa học: "Canine biphasic synovial sarcoma: case report and immunohistochemical characterization"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Canine biphasic synovial sarcoma: case report and immunohistochemical characterization | J. Vet. Sci. 2004 5 2 173-180 JOURNAL OF Veterinary Science Canine biphasic synovial sarcoma case report and immunohistochemical characterization Panayiotis Loukopoulos 2 3 Hock Gan Heng1 3 Habibah Arshad4 Division of Veterinary Pathology and Anatomy School of Veterinary Science The University of Queensland St. Lucia 4072 Australia 1 Faculty of Veterinary Medicine Universiti Putra Malaysia 43400 Serdang Selangor Darul Ehsan Malaysia The clinical radiological and pathologic features of a biphasic synovial sarcoma in the left elbow joint of a two-year-old male Rottweiler are presented. The tumor showed positive immunoreactivity for vimentin Epithelial Membrane Antigen EMA p53 and PCNA while it was negative for the cytokeratin used S-100 Rb and p21. Immunohistochemistry for EMA allowed the identification of epithelioid components of synovial sarcoma and may therefore contribute in establishing a diagnosis of biphasic synovial sarcoma. Intratumoral variation in PCNA immunoreactivity was minimal indicating that the various tumor components proliferate at more or less similar rates. Overall the characterized immunohistochemical profile for canine synovial sarcoma not defined previously may provide clues to the histogenesis of the phenotypically mesenchymal and epithelial elements of the tumor and may be of value in the differential diagnosis of challenging cases decreasing the risk of under- and mis-diagnosis. Although more cases need to be studied to determine whether there is a consistent pattern of immunostaining in canine synovial sarcoma its potential significance is discussed in relation to the histogenesis molecular pathology and differential diagnosis of canine synovial sarcoma. Keywords Epithelial Membrane Antigen dogs immunohistochemistry neoplasms p53 radiology pathology biphasic synovial sarcoma Corresponding author Phone 81-3-3542-2511 ext 4210 Fax 81-3-3248-2463 E-mail ploukopo@ and LoukopoulosP@ Current address 2Pathology .