tailieunhanh - Báo cáo khoa học: "Hypoglycemic effects of vanadium on alloxan monohydrate induced diabetic dogs"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Hypoglycemic effects of vanadium on alloxan monohydrate induced diabetic dogs | J. Vet. Set. 2006 7 4 391-395 JOURNAL OF Veterinary Science Hypoglycemic effects of vanadium on alloxan monohydrate induced diabetic dogs Joo-Min Kim Jin-Young Chung Sook-Yeon Lee Eun-Wha Choi Min-Kyu Kim Cheol-Yong Hwang Hwa-Young Youn Department of Internal Medicine College of Veterinary Medicine Seoul National University Seoul 151-742 Korea The hypoglycemic effects after oral administration of vanadium have been studied previously in many species such as rats mice and even humans. However there has been no prior report on the glucose lowering effect of vanadium on diabetic dogs. Therefore the purpose of this study was to evaluate the hypoglycemic effects of oral vanadium on diabetic dogs. Diabetes mellitus in the dogs studied was induced by alloxan monohydrate intravenous injection. The dogs were divided into two groups one was the diabetic control DC group n 4 and the other was the vanadium treated DV group n 6 . Fresh water was supplied to the dogs in the DC group but sodium metavanadate solution mg ml was given to the dogs in DV group from one week after the alloxan injection. The fasting glucose levels fructosamine and serum chemistry profiles were compared between the two groups weekly for three weeks. The fasting blood glucose levels in DV group were significantly lower than those in the DC group p . Fructosamine levels in the DV group were also lower than those in the DC group p . The serum chemistry profiles were not significantly different in comparisons between the two groups. However the cholesterol levels were significantly lower in the DV group compared to the DC group p . Our findings showed that oral vanadium administration had a hypoglycemic effect on chemically induced diabetic dogs. Key words alloxan diabetes mellitus dogs vanadium Introduction Diabetes mellitus is one of the most common endocrine diseases in dogs. Type I or insulin-dependent diabetes mellitus IDDM is caused by the lack of insulin and results from the .