tailieunhanh - Báo cáo khoa hoc:" Alternative models for QTL detection in livestock. III. Heteroskedastic model and models corresponding to several distributions of the QTL effect"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Alternative models for QTL detection in livestock. III. Heteroskedastic model and models corresponding to several distributions of the QTL effect | Genet. Sei. Evol. 31 1999 341-350 Inra Elsevier Paris 341 Original article Alternative models for QTL detection in livestock. III. Heteroskedastic model and models corresponding to several distributions of the QTL effect Bruno Goffineta Pascale Le Royb Didier Boichardb Jean Michel Eisenc Brigitte Mangin a a Biometric et intelligence artificielle Institut national de la recherche agronomique BP27 31326 Castanet-Tolosan France b Station de génétique quantitative et appliquée Institut national de la recherche agronomique 78352 Jouy-en-Josas France c Station d amelioration génétique des animaux Institut national de la recherche agronomique BP27 31326 Castanet-Tolosan France Received 20 November 1998 accepted 22 April 1999 Abstract - This paper describes two kinds of alternative models for QTL detection in livestock an heteroskedastic model and models corresponding to several hypotheses concerning the distribution of the QTL substitution effect among the sires a fixed and limited number of alleles or an infinite number of alleles. The power of different tests built with these hypotheses were computed under different situations. The genetic variance associated with the QTL was shown in some situations. The results showed small power differences between the different models but important differences in the quality of the estimations. In addition a model was built in a simplified situation to investigate the gain in using possible linkage disequilibrium. Inra Elsevier Paris half-sib families heteroskedastic model linkage disequilibrium QTL detection Resume Modèles alternatifs pour la detection de QTL dans les populations animales. III. Modèle hétéroscédastique et modèles correspondant à differentes distributions de 1 effet du QTL. Ce papier décrit deux types de modèles alternatifs pour la detection de QTL dans les populations animales un modèle hétéroscédastique Correspondence and reprints E-mail elsen@ 342 B. Goffinet et al. d une part et des modèles .