tailieunhanh - Báo cáo khoa hoc:" Is the A porcine RN locus a pleiotropic QTL? Bayesian marker assisted segregation analysis"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Is the A porcine RN locus a pleiotropic QTL? Bayesian marker assisted segregation analysis | Genet. Sei. Evol. 30 1998 257-273 @ Inra Elsevier Paris 257 Original article Is the porcine RN locus a plệiotropic QTL A Bayesian marker assisted segregation analysis Norbert Reinsch Christian Looft Iris Rudat Ernst Kalm Institut fiir Tierzucht und Tierhaltung der Christian-Albrechts-Universităt ZU Kiel OlshausenstraCe 40 24098 Kiel Germany Received 5 March 1997 accepted 18 March 1998 Abstract - The question of possible pleiotropic effects of the porcine RN locus on production traits was addressed. Chromosome 15 microsatellite data mapping results and performance data from the Kiel RN mapping experiment were used to compare heterozygous RN rn carrier animals and rn rn non-carriers. Progenies from 14 Hampshire X Piétrain sires all of which were heterozygous at both the RN and RYR1 loci were recorded for 24 traits. Dams were either Landrace Large White crossbreds or Landrace or Large White purebreds. The number of progeny with valid records ranged from 323 to 418 depending on the trait. A mixed polygenic-major gene inheritance model was applied using a Bayesian approach. Reflectance and terminal pH were lowered in carriers. Additionally a mm increase in muscle depth in the loin an enlargement of loin eye area by cm2 and a increase in estimated lean meat content due to the RN allele were observed. It was shown that the increased lean meat content was not high enough to outweigh the economic loss from poor technological yield. The proportion of genetic variance in progeny which could be attributed to the RN locus ranged from 5 to 55 More than 40 of the total genetic variance in eye muscle depth was generated by the joint action of RN and RYR1. This is discussed with respect to uniformity of end products in a crossbreeding scheme. The results suggest that not only loci which are involved in glycogen metabolism but also those which are related to muscular development may be regarded as possible candidate genes for the RN locus. Inra Elsevier Paris major .