tailieunhanh - Báo cáo khoa học: "Influence of endotoxin induced fever on the pharmacokinetics of intramuscularly administered cefepime in rabbits

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Influence of endotoxin induced fever on the pharmacokinetics of intramuscularly administered cefepime in rabbits | J. Vet. Sá. 2006 7 2 157-160 JOURNAL OF Veterinary Science Modulatory effects of chitosan adipate on the T and B lymphocyte subsets in mice Bozena Obminska-Mrukowicz Marianna Szczypka Bartosz Gawẹda Department of Biochemistry. Pharmacology and Toxicology. Faculty of Veterinaiy Medicine. Agricultural University. Norwida 31. 50-375 Wroclaw. Poland This study examined the subsets of T lymphocytes in the thymus spleen and mesenteric lymph nodes as well as the subsets of B lymphocytes in the spleen and mesenteric lymph nodes in mice administered chitosan adipate 20 mg kg intraperitoneally once or four times at 24 h intervals. The results showed that chitosan adipate decreased the percentage of immature CD4 CD8 thymic T cells and increased the percentage of mature CD4 and CD8 thymocytes. The most significant stimulating effect was observed after four injections. A single exposure to chitosan adipate increased the percentage of CD4 mesenteric lymph node cells but four injections of the drug increased the percentage of CD4 and CD8 mesenteric lymph node cells. Chitosan adipate had no effect on the subset of splenic T cells. In contrast chitosan adipate administered either once or four times increased the percentage of CD19 splenocytes but had no effect on the percentage of CD19 mesenteric lymph node cells. Overall chitosan adipate induces the maturation and differentiation of thymocytes and regulates the number of B splenic cells and lymph node T cells ứrespective of the number of doses. Key words B and T lymphocyte subsets chitosan mice Introduction A reduction in the number and function of immune cells can lead to a secondary immunological deficency. which manifests as recurrent infections autoaggresion and cancer diseases. In the last three decades a wide variety of substances both natural calf thymus extract lysozyme dimer and synthetic levamisole. isoprinosine . have been introducted in order to modify the acquired defects of the immune cell activity. Corresponding .