tailieunhanh - Báo cáo khoa học: "Guided bone regeneration with beta-tricalcium phosphate and poly L- lactide-co-glycolide-co-epsilon-caprolactone membrane in partial defects of canine humerus"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Guided bone regeneration with beta-tricalcium phosphate and poly L- lactide-co-glycolide-co-epsilon-caprolactone membrane in partial defects of canine humerus | J. Vet. Set. 2006 7 1 73-77 JOURNAL OF Veterinary Science Guided bone regeneration with beta-tricalcium phosphate and poly L-lactide-co-glycolide-co-epsilon-caprolactone membrane in partial defects of canine humerus Taehoon Oh Md. Mizanur Rahman Ji-Hey Lim Mi-Sun Park Dae-Yong Kim Jung-hee Yoon Wan Hee Kim1 Masanori Kikuchi4 Junzo Tanaka4 Yoshihisa Koyama5 Oh-Kyeong Kweon Laboratory of Veterinary Surgery 2 Veterinary Pathology ancTVetermary Radiology College of Veterinary Medicine Seoul National University Seoul 151-742 Korea 4Biomaterial Center National Institute for Materials Science Tsukuba Ibaraki 305-0044 Japan department of Biomechanical Engineering Institute of Biomaterials and Bioengineering Tokyo Medical and Dental University Chiyoda Tokyo 101-0062 Japan This study was performed to evaluate the effect of betatricalcium phosphate and poly L-lactide-co-glycolide-co-epsilon-caprolactone TCP PLGC membrane in the repair of partial bone defects in canine proximal humerus. Three adult mixed-breed dogs were used during the experimental period. The length of the defect was quarter of the full length of humerus and width of the defect was quarter of middle diameter of the lateral aspect of humerus. The humeri of each dog were divided into treatment TCP PLGC and control groups. The defect was covered with TCP PLGC membrane in treatment group. To evaluate regeneration of the bone computerized tomography CT and histopathologic examination were performed. The radiopaque lines were appeared at the original defect sites in TCP PLGC group but below the original site in control at 4th week. Radiopacity and thickness of the defect sites and radiopaque lines were more increased at 8th week than those of 4th week. Histopathologic findings revealed fibrous connective tissue migration into the defect and the migration inhibited the structure of new cortex to be placed in the original level in control whereas new cortex growth was found in the level of original line in TCP PLGC .