tailieunhanh - Báo cáo khoa học: "Glutamate and GABA concentrations in the cerebellum of novel ataxic mutant Pogo mice"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Glutamate and GABA concentrations in the cerebellum of novel ataxic mutant Pogo mice | J. Vet. Sci. 2003 4 3 209-212 JOURNAL OF Veterinary Science Glutamate and GABA concentrations in the cerebellum of novel ataxic mutant Pogo mice Ki-Hyung Kim Jeoung-Hee Ha1 Seung-Hyuk Chung Chul-Tae Kim Sun-Kyung Kim Byung-Hwa Hyun2 Kazuhiko Sawada3 Yoshihiro Fukui3 Il-Kwon Park4 Geun-jwa Lee5 Bum-Kyeong Kim Nam-Seob Lee and Young-Gil Jeong Department of Anatomy Pathology College of Medicine Konyang Univiversity Nonsan 320-711 Korea Department of Pharmacology College of Medicine Yeungnam University Gyeongsan 712-749 Korea Genetic Resource Center KRIBB Daejon 305-333 Korea Department of Anatomy University of Tokushima School of Medicine Tokushima Japan . Paichai University RRC Daejeon 302-161 Korea 5Chungnam Livestock Veterinary Service institute Hongsung 350-821 Korea The Pogo mouse is an autosomal recessive ataxic mutant that arose spontaneously in the inbred KJR MsKist strain derived originally from Korean wild mice. The ataxic phenotype is characterized by difficulty in maintaining posture and side to side stability faulty coordination between limbs and trunk and the consequent inability to walk straight. In the present study the cerebellar concentrations of glutamate and GABA were analyzed since glutamate is a most prevalent excitatory neurotransmitter whereas Y-aminobutyric acid GABA is one of the most abundant inhibitory neurotransmitters which may be the main neurotransmitters related with the ataxia and epilepsy. The concentration of glutamate of cerebellum decreased significantly in ataxic mutant Pogo mouse compared to those of control mouse. However GABA concentration was not decrease. These results suggested that the decrease in glutamate concentration may contribute to ataxia in mutant Pogo mouse. Key words Pogo glutamate GABA cerebellum Introduction The Pogo mouse is an autosomal recessive ataxic mutant that arose spontaneously in the inbred KJR MsKist strain derived originally from Korean wild mice. The ataxic phenotype is characterized by .