tailieunhanh - Báo cáo khoa học: "Oligodendroglioma in a French bulldog"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Oligodendroglioma in a French bulldog | J. Vet. Sci. 2003 4 2 195-197 HDEDSSniQH Veterinary Science - Short Communication - CHigodendroglioma in a French Bulldog Chun-ho Park Department of Pathobiological Sciences School of Veterinary Medicine University of Wisconsin Received May 23 2003 July 20 2003 Abstract A 5-year-old male French bulldog with bradycardia dyspnea and decerebrate rigidity was necropsied. Macroscopic findings were restricted to the brain and a single mass 5 cm in size was observed mainly at the right cingulum with prominently protruding into the dilated right lateral ventricle. The mass was grayish white in color soft and gelatinous but not clearly delineated. Microscopically the mass consisted of diffuse proliferated neoplastic oligodendroglial cells characterized by small round and hyperchromatic nuclei with clear cytoplasm and the cells aggressively invaded into the adjacent parenchyma. Immunohistochemistry demonstrated that most of the neoplastic cells were positive for S-100 protein vimentin neuron specific enolase NSE and neurofilament protein NFP . From these findings the mass was diagnosed as oligodendroglioma. Key words oligodendroglioma cerebrum dog In animals neuroectodermal tumors are most common in dogs 6 . Of these neoplasms astrocytomas comprise the majority of canine glioma in the United State whereas oligodendrogliomas are most frequently diagnosed in Switzerland 6 A predilection for glial tumors in brachycephalic dog breeds such as Boxers Terriers and Bulldogs has been recognized 1 5 Oligodendroglioma is usually noted in middle aged to old dogs 2 7 11 and tend to locate in the cerebral white matter particularly around the lateral ventricle 5 8 However distinguishing between oligodendroglioma and astrocytoma is sometimes difficult 6 because they share several histomorphological features including high cellularity necrosis high mitotic rate and prominent proliferation of glomeruloid vessels 7 . In addition the presence of intermingled astrocytic cells .