tailieunhanh - Báo cáo khoa học: "Immobilization with ketamine HCl and tiletamine-zolazepam in cynomolgus monkeys"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Immobilization with ketamine HCl and tiletamine-zolazepam in cynomolgus monkeys | J. Vet. Sci. 2003 4 2 187-191 .1 o f R N A L F Veterinary Science Immobilization with Ketamine HQ and Tiletamine-Zolazepam in Cynomolgus Monkeys Jae-il Lee Sung-hyeok Hong Soo-jin Lee Young-Silk Kim and Myung-cheol Kim Laboratory of Veterinary Surgery College of Veterinary Medicine Chungnam National University Daejeon 305-764 Korea Received March 4 2003 Accepted July 2 2003 Abstract To compare the effects of ketamine and tiletamine-zolazepam TZ drugs widely used for the chemical restraint and immobilization of primates on various physiological parameters and blood gas values in cynomolgus monkeys Macaco. facicular is . Rectal temperature heart rate respiration rate and blood gas analysis were measured before treatment and at 1 10 20 30 40 50 and 60 min after administration. Additionally in both groups induction and maintenance times were compared. Heart rate respiration rate rectal temperature pH and pCC 2 were not significant different in the two groups. However PƠ2 in the ketamine-treated group was significantly lower at 30 and 40 min than in the TZ-treated group. The induction time was short in both groups and the maintenance time was longer in the TZ-treated group min than in the ketamine-treated group min . However decreased rectal temperatures must be watched and prevented following TZ administration to qynomolgus monkeys. It was considered that ketamine may be useful for short duration anesthesia including handling physical examination blood sampling and TZ may be useful for prolonged anesthesia including minor surgery and other surgical procedure. Key words cynomolgus monkey immobilization ketamine HC1 tiletamine-zolazepam Introduction The cynomolgus monkey Macaco fascicularis is used widely in research for respiratory and toxicological work 18 Non-human primates present special hazards to handlers particularly the danger of bites and zoonotic infection 18 . Restraint or immobilization is very important to minimize harm incurred to humans