tailieunhanh - Báo cáo khoa học: "Effects of Tributyltin Chloride on the Reproductive System in Pubertal Male Rats"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Effects of Tributyltin Chloride on the Reproductive System in Pubertal Male Rats | J. Vet. Sci. 2003 4 1 29-34 JOURNAL OF Veterinary Science Effects of Tributyltin Chloride on the Reproductive System in Pubertal Male Rats Wook-joon Yu Sang-yoon Nam Young-chul Kim1 Beom-jun Lee and Young-won Yun College of Veterinary Medicine and Research Institute of Veterinary Medicine Chungbuk National University Cheongju 361-763 Korea Department of Public Health College of Natural Sciences Keimyung University Daegu 704-701 Korea Received August 26 2002 Accepted February 5 2003 Abstract Detrimental effects of tributyltin TBT chloride on the reproductive system were investigated in pubertal male rats. Sixty Sprague-Dawley rats aged with 35 days were assigned to six different groups negative control receiving vehicle p ositive control receiving methyltestosterone 10 mg kg . TBT chloride 5 mg kg . 10 mg kg . and 20 mg kg . and a combination of TBT chloride 10 mg kg . and flutamide 10 mg kg . The animals were treated with test compounds by oral gavage d aily for 10 days and sacrificed on the next day of the final treatment. The treatment with TBT chloride at the doses of 10 and 20 mg kg . significantly decreased seminal vesicle w eights compared to the negative control. The combined treatment of TBT chloride and flutamide caused a significant decrease in accessory sex organ weights compared to the control and TBT chlorid e treatments. The treatment with TBT chloride or in the combination with flutamide increased detached debris and sloughed ce lls in the tubules of epididymis and narrow ed seminal vesicles. In addition the combined treatment with TBT chloride and flutamide caused a noticeable increase in serum androgen level compared to the negative control. These results suggest that TBT chloride exposed during pubertal period cause p artial reproductive disorders in male rats. Key words accessory sex organ flutamide methyltestosterone TBT chloride Corresponding author Young-won Yun Department of Veterinary Physiology College of Veterinary .

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