tailieunhanh - Age-Related Macular Degeneration - part 8

Trong nghiên cứu Beaver Dam Eye, sau khi kiểm soát về tuổi tác, tổng cholesterol trong huyết thanh được nghịch liên quan đến AMD đầu ở phụ nữ (OR, 0,89; 95% CI, 0,80-0,98), trong khi các tỷ lệ cholesterol tổng số cholesterol / HDL là tỷ lệ nghịch | Risk Factors for AMD and CNV 377 In the Beaver Dam Eye Study after controlling for age total serum cholesterol was inversely related to early AMD in women OR 95 CI whereas the total cholesterol HDL cholesterol ratio was inversely related OR 95 CI and HDL cholesterol was positively related to early AMD in men 113 . The reasons for these associations are not clear although a possible explanation is selective survival. Because persons with higher cholesterol levels or lower HDL cholesterol levels are at higher risk of cardiovascular death than persons with normal levels of cholesterol a positive relationship may have been obscured. Serum cholesterol or HDL cholesterol was not related to neovascular AMD or geographic atrophy in the same study 113 . The Age-Related Macular Degeneration Risk Factors Study Group found neovascu-lar AMD but not nonneovascular AMD to be positively associated with high-density lipoprotein level OR 95 CI and dietary cholesterol level OR 95 CI 19 . In the Beaver Dam Eye Study persons with intake of saturated fat and cholesterol in the highest compared with the lowest quintile had odds ratio of 95 CI and 95 CI for early AMD respectively after adjusting for age and beer intake 118 . However no significant association between these intakes was found with late AMD 118 . The findings in this study concur with the Blue Mountains Eye Study which found that total and saturated fat intake were associated with a borderline significant increase in risk for early AMD ORs 95 CI for highest compared to lowest quintiles of intake and respectively but not for late AMD 119 . A significant association p for trend for increasing prevalence of early AMD with increasing monounsaturated fat intake was observed. Cholesterol intake was associated with a borderline significant increase in risk for late AMD OR 95 CI for highest compared to lowest quintiles of