tailieunhanh - Báo cáo sinh học: " Macrophages and cytokines in the early defence against herpes simplex virus"

Macrophages and cytokines in the early defence against herpes simplex virus | Virology Journal BioMed Central Review Open Access Macrophages and cytokines in the early defence against herpes simplex virus Svend Ellermann-Eriksen Address Department of Clinical Microbiology Aarhus University Hospital Skejby Sygehus Brendstrupgaardsvej 100 DK-8200 Aarhus N. Denmark Email Svend Ellermann-Eriksen - sea@ Corresponding author Published 03 August 2005 Received 05 July 2005 Accepted 03 August 2005 Virology Journal 2005 2 59 doi 1743-422X-2-59 This article is available from http content 2 1 59 2005 Ellermann-Eriksen licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Herpes simplex virus HSV type I and 2 are old viruses with a history of evolution shared with humans. Thus it is generally well-adapted viruses infecting many of us without doing much harm and with the capacity to hide in our neurons for life. In rare situations however the primary infection becomes generalized or involves the brain. Normally the primary HSV infection is asymptomatic and a crucial element in the early restriction of virus replication and thus avoidance of symptoms from the infection is the concerted action of different arms of the innate immune response. An early and light struggle inhibiting some HSV replication will spare the host from the real war against huge amounts of virus later in infection. As far as such a war will jeopardize the life of the host it will be in both interests including the virus to settle the conflict amicably. Some important weapons of the unspecific defence and the early strikes and beginning battle during the first days of a HSV infection are discussed in this review. Generally macrophages are orchestrating a multitude of anti-herpetic actions during the first .