tailieunhanh - Báo cáo sinh học: " Inhibition of Henipavirus fusion and infection by heptad-derived peptides of the Nipah virus fusion glycoprotein"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Inhibition of Henipavirus fusion and infection by heptad-derived peptides of the Nipah virus fusion glycoprotein | Virology Journal BioMed Central Research Open Access Inhibition of Henipavirus fusion and infection by heptad-derived peptides of the Nipah virus fusion glycoprotein Katharine N Bossartt2 Bruce A Mungall11 Gary Crameri1 Lin-Fa Wang1 Bryan T Eaton1 and Christopher C Broder 2 Address 1CSIRO Livestock Industries Australian Animal Health Laboratory Geelong Victoria 3220 Australia and 2Department of Microbiology and Immunology Uniformed Services University Bethesda MD 20814 USA Email Katharine N Bossart - Bruce AMungall - Gary Crameri - Lin-Fa Wang - Bryan T Eaton - Christopher C Broder - cbroder@ Corresponding author tEqual contributors Published 18 July 2005 Received 24 May 2005 Virology Journal 2005 2 57 doi 1743-422X-2-57 Accepted 18 July 2005 This article is available from http content 2 1 57 2005 Bossart et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The recent emergence of four new members of the paramyxovirus family has heightened the awareness of and re-energized research on new and emerging diseases. In particular the high mortality and person to person transmission associated with the most recent Nipah virus outbreaks as well as the very recent re-emergence of Hendra virus has confirmed the importance of developing effective therapeutic interventions. We have previously shown that peptides corresponding to the C-terminal heptad repeat HR-2 of the fusion envelope glycoprotein of Hendra virus and Nipah virus were potent inhibitors of both Hendra virus and Nipah virus-mediated membrane fusion using recombinant expression systems. In the current .