tailieunhanh - Báo cáo hóa học: " Studies on Preparation of Photosensitizer Loaded Magnetic Silica Nanoparticles and Their Anti-Tumor Effects for Targeting Photodynamic Therap"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Studies on Preparation of Photosensitizer Loaded Magnetic Silica Nanoparticles and Their Anti-Tumor Effects for Targeting Photodynamic Therap | Nanoscale Res Lett 2009 4 400-408 DOI s11671-009-9254-5 NANO EXPRESS Studies on Preparation of Photosensitizer Loaded Magnetic Silica Nanoparticles and Their Anti-Tumor Effects for Targeting Photodynamic Therapy Zhi-Long Chen Yun Sun Peng Huang Xiao-Xia Yang Xing-Ping Zhou Received 13 November 2008 Accepted 8 January 2009 Published online 31 January 2009 to the authors 2009 Abstract As a fast developing alternative of traditional therapeutics photodynamic therapy PDT is an effective noninvasive nontoxic therapeutics for cancer senile macular degeneration and so on. But the efficacy of PDT was compromised by insufficient selectivity and low solubility. In this study novel multifunctional silica-based magnetic nanoparticles SMNPs were strategically designed and prepared as targeting drug delivery system to achieve higher specificity and better solubility. 2 7 12 18-Tetra-methyl-3 8-di- 1-propoxyethyl -13 17-bis- 3-hydroxypropyl porphyrin shorted as PHPP was used as photosensitizer which was first synthesized by our lab with good PDT effects. Magnetite nanoparticles Fe3O4 and PHPP were incorporated into silica nanoparticles by microemulsion and sol-gel methods. The prepared nanoparticles were characterized by transmission electron microscopy X-ray diffraction Fourier transform infrared spectroscopy and fluorescence spectroscopy. The nanoparticles were approximately spherical with 20-30 nm diameter. Intense fluorescence of PHPP was monitored in the cytoplasm of SW480 cells. The nanoparticles possessed good biocompatibility and could generate singlet oxygen to cause remarkable photodynamic anti-tumor effects. These suggested that PHPP-SMNPs had great potential as effective drug delivery system in targeting photodynamic therapy . Chen Y. Sun P. Huang . Yang . Zhou Department of Pharmaceutical Science and Technology College of Chemistry and Biology Donghua University Shanghai 201620 China e-mail zlchen1967@ . Zhou e-mail xpzhou@