tailieunhanh - Báo cáo hóa học: " pH-Sensitive Micelles Based on Double-Hydrophilic Poly(methylacrylic acid)-Poly(ethylene "

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: pH-Sensitive Micelles Based on Double-Hydrophilic Poly(methylacrylic acid)-Poly(ethylene | Nanoscale Res Lett 2009 4 341-343 DOI S11671-009-9249-2 NANO EXPRESS pH-Sensitive Micelles Based on Double-Hydrophilic Poly methylacrylic acid -Poly ethylene glycol -Poly methylacrylic acid Triblock Copolymer Youhua Tao Ren Liu Xiaoya Liu Mingqing Chen Cheng Yang Zhongbin Ni Received 30 November 2008 Accepted 2 January 2009 Published online 21 January 2009 to the authors 2009 Abstract pH-sensitive micelles with hydrophilic core and hydrophilic corona were fabricated by self-assembling of triblock copolymer of poly methylacrylic acid -poly eth-ylene glycol -poly methylacrylic acid at lower solution pH. Transmission electron microscopy and laser light scattering studies showed micelles were in nano-scale with narrow size distribution. Solution pH value and the micelles concentration strongly influenced the hydrodynamic radius of the spherical micelles 48-310 nm . A possible mechanism for the formation of micelles was proposed. The obtained polymeric micelle should be useful for biomedical materials such as carrier of hydrophilic drug. Keywords Self-assembly Micelles Double-hydrophilic Triblock copolymers The self-assembly behavior of double-hydrophilic block copolymers under the influence of a given external stimulus such as a change in pH temperature or ionic strength has attracted considerable interests due to their potential application in areas such as biomimetic chemistry Y. Tao R. Liu X. Liu H M. Chen C. Yang Z. Ni School of Chemical and Material Engineering Jiangnan University Wuxi 214122 People s Republic of China e-mail lxy@ Y. Tao State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun Jilin 130022 People s Republic of China R. Liu X. Liu M. Chen C. Yang Z. Ni State Key Laboratory of Food Science and Technology Jiangnan University Wuxi 214122 People s Republic of China molecular switch and controlled drug delivery 1-4 . Many systems such as poly ethylene .