tailieunhanh - Age-Related Macular Degeneration (part 5)

Lưu giữ xảy ra trong vòng 5 phút với sự tiến triển đến các phân đoạn bên ngoài trong vòng 20 phút. Không có BPD-MA được phát hiện trong màng mạch hoặc các tế bào nhận kích thích ánh sáng ở 2 giờ | Photodynamic Therapy 209 choroid and RPE was confirmed using fluorescence microscopy in rabbits. Retention occurred within 5 min with progression to the outer segments within 20 min. No BPD-MA was detected within the choroid or photoreceptors at 2 h however a small trace was detected in the RPE at 24 h 13 . A similar pharmacokinetic pattern was observed in monkeys using in vivo fluorescence imaging 14 . The long-term effects on the retina and choroid were evaluated in cynomolgus monkeys with experimental CNV 15 . Fundus photography and angiography analyses were performed at 24 h and then weekly for 4-7 weeks following a treatment of mg BPD-MA kg and a fluence of 150 J cm2. Eyes were examined histologically at the end of the follow-up period. CNV closure also resulted in closure of the choriocapillaris with damage occurring to RPE cells. However these areas appeared to regenerate somewhat in the 4-7week study period. Of 28 CNV lesions followed for 4 weeks 72 remained closed. Lesion retreatment was determined to be needed to sustain vessel closure. The effect of three treatments was evaluated in disease-free primate eyes 16 . Treatments using sensitizer doses of 6 12 or 18 mg m2 20 min after drug infusion and a fluence of 100 J cm2 were performed every 2 weeks. A cumulative dose response was observed damage to the retina choroid and optic nerve was limited in the 6 mg m2 sensitizer subgroup while the higher-dose groups exhibited severe choriocapillaris and photoreceptor damage at 6 weeks. F. Tin Ethyl Etiopurpurin Purlytin SnET2 The purpurin SnET2 has been clinically evaluated for the palliation of symptoms associated with recurrent cutaneous metastatic breast cancer 17 . The sensitizer possesses a large extinction coefficient at 660 nm and since it is hydrophobic it is formulated in a lipid emulsion. SnET2-mediated PDT was found to occlude CNV experimentally induced in rats 18 . SnET2 was intravenously administered at a dose of 1 mg kg the eyes were then .