tailieunhanh - The Gale Encyclopedia of Neurological Disorders vol 1 - part 10

Đối với sử dụng trong bệnh đa xơ cứng, interferon beta-1a được tiêm vào cơ bắp (tiêm bắp), và beta1b được tiêm dưới da (tiêm dưới da). Việc tiêm thường được mỗi ngày. Liều khuyến cáo đối với beta-1a và 1b là 0,03 mg và 0,25 mg, tương ứng. | Interferons For use in multiple sclerosis interferon beta-1a is injected into the muscle intramuscular injection and beta-1b is injected just below the skin subcutaneous injection . The injections are usually given every other day. The recommended dose for beta-1a and 1b is mg and mg respectively. Initial doses of beta-1b should be far less . mg with a gradual increase in dose over six weeks. Precautions Patients who have had seizures or who are at risk for a seizure should be closely monitored following the injection of interferon as should those with heart disorders such as angina congestive heart failure or an irregular heartbeat. It is not known if interferon can be expressed in breast milk. Concerned mothers may opt to cease breast-feeding while receiving interferon therapy. Side effects Interferon beta 1-a and 1-b commonly produce flulike symptoms including fever chills sweating muscle aches and tiredness. These side effects tend to diminish with time. Menstrual cycle changes have also been documented in a significant number of women. Far less commonly interferon beta 1-a and 1-b can produce suicidal feelings in someone who is already clinically depressed. Death of cells around an injection site necrosis can occur as can swelling and bruising. Allergic reactions are possible. The massive and sometimes fatal allergic reaction termed anaphylaxis occurs rarely. Other side effects include liver and thyroid malfunction and altered blood chemistry fewer platelets and red and white blood cells . Interactions As of December 2003 drug interaction studies have not been conducted. Resources BOOKS Lotze M. T. R. M. Dallal J. M. Kirkwood and J. C. Flickinger. Cutaneous Melanoma. In Principles and Practice of Oncology edited by V. T. DeVita S. A. Rosenberg and S. Hellmon. Philadelphia Lippincott 2001. PERIODICALS Aguilar R. F. Interferons in Neurology. Rev Invest Clin 52 no. 6 2000 665-679. Polman C. H. and B. M. J. Uitdehaag. Drug Treatment of Multiple