tailieunhanh - Báo cáo hóa học: " The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle Cells"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle Cells | Nanoscale Res Lett 2009 4 70-77 DOI s11671-008-9204-7 NANO EXPRESS The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle Cells Song Zhang Xiangjian Chen Chunrong Gu Yu Zhang Jindan Xu Zhiping Bian Di Yang Ning Gu Received 17 September 2008 Accepted 29 October 2008 Published online 2 December 2008 to the authors 2008 Abstract Recently magnetic nanoparticles of iron oxide Fe3O4 c-Fe2O3 have shown an increasing number of applications in the field of biomedicine but some questions have been raised about the potential impact of these nanoparticles on the environment and human health. In this work the three types of magnetic nanoparticles DMSA-Fe2O3 APTS-Fe2O3 and GLU-Fe2O3 with the same crystal structure magnetic properties and size distribution was designed prepared and characterized by transmission electronic microscopy powder X-ray diffraction zeta potential analyzer vibrating sample magnetometer and Fourier transform Infrared spectroscopy. Then we have investigated the effect of the three types of magnetic nanoparticles DMSA-Fe2O3 APTS-Fe2O3 and GLU-Fe2O3 on smooth muscle cells SMCs . Cellular uptake of nanoparticles by SMC displays the dose the incubation time and surface property dependent patterns. Through the thin section TEM images we observe that DMSA-Fe2O3 is incorporated into the lysosome of SMCs. The magnetic nanoparticles have no inflammation impact but decrease the viability of SMCs. The other questions about Song Zhang and Xiangjian Chen contributed equally to this work. S. Zhang Y. Zhang N. Gu State Key Laboratory of Molecule and Biomolecule Electronics Jiangsu Provincial Laboratory for Biomaterials and Devices Southeast University 210096 Nanjing People s Republic of China e-mail guning@ X. Chen C. Gu J. Xu Z. Bian D. Yang Institute of Cardiovascular Disease The First Affiliated Hospital of Nanjing Medical University 210029 Nanjing People s Republic of China e-mail dyang@ metabolism and other impacts will be