tailieunhanh - Báo cáo sinh học: " Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection | BioMed Central Virology Journal Research Open Access Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection W James Cook1 2 Martha F Kramer3 4 Russell M Walker1 Timothy J Burwell1 Holly A Holman4 Donald M Coen3 and David M Knipe 4 Address Millennium Pharmaceuticals Inc. Cambridge MA 02139 USA 2GlycoFi Inc. 21 Lafayette Street Suite 200 Lebanon NH 03766 USA 3Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School Boston MA 02115 USA and 4Department of Microbiology and Molecular Genetics Harvard Medical School Boston MA 02115 USA Email W James Cook - JCook@ Martha F Kramer - martha_kramer@ Russell M Walker - Walker@ Timothy J Burwell - Burwell@ Holly A Holman - holmanholly@ Donald M Coen - don_coen@ David M Knipe - david_knipe@ Corresponding author Published 23 September 2004 Received 25 May 2004 Accepted 28 May 2004 Virology Journal 2004 1 5 doi 1743-422X-1-5 This article is available from http content 1 1 5 2004 Cook et al licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Inflammatory cytokines and infiltrating T cells are readily detected in herpes simplex virus HSV infected mouse cornea and trigeminal ganglia TG during the acute phase of infection and certain cytokines continue to be expressed at lower levels in infected TG during the subsequent latent phase. Recent results have shown that HSV infection activates Toll-like receptor signaling. Thus we hypothesized that chemokines may be broadly expressed at both primary sites and latent sites of HSV infection for prolonged periods of time. Real-time reverse .