tailieunhanh - Báo cáo hóa học: "Effects of Pin-up Oxygen on [60]Fullerene for Enhanced Antioxidant Activity"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Effects of Pin-up Oxygen on [60]Fullerene for Enhanced Antioxidant Activity | Nanoscale Res Lett 2008 3 237-241 DOI S11671-008-9142-4 NANO EXPRESS Effects of Pin-up Oxygen on 60 Fullerene for Enhanced Antioxidant Activity Kenji Matsubayashi Tadashi Goto Kyoko Togaya Ken Kokubo Takumi Oshima Received 16 May 2008 Accepted 12 June 2008 Published online 4 July 2008 to the authors 2008 Abstract The introduction of pin-up oxygen on C60 such as in the oxidized fullerenes C60O and C60On induced noticeable increase in the antioxidant activity as compared to pristine C60. The water-soluble inclusion complexes of fullerenes C60O and C60On reacted with linoleic acid per-oxyl radical and times faster respectively. Keywords Fullerene C60 Oxidized fullerene C60O Antioxidant y-Cyclodextrin PVP Introduction Fullerenes and its derivatives are well known as a new class of antioxidants and they have attracted considerable attention in biologic applications due to their high reactivity toward radicals 1 especially reactive oxygen species ROS such as superoxide 2 hydroxyl radical 3 peroxyl radicals 4 and nitric oxide 5 . These harmful radicals attack lipids proteins DNA and other biologic tissues and organs. It has been found that watersoluble fullerenes can be used as potential antioxidants and neuroprotective drugs against degenerative diseases related to oxidative stress 6-11 . Thus water-soluble fullerenes including host-guest inclusion complexes are promising candidates for practical use as antioxidants. K. Matsubayashi T. Goto K. Togaya K. Kokubo El T. Oshima Division of Applied Chemistry Graduate School of Engineering Osaka University 2-1 Yamadaoka Suita Osaka 565-0871 Japan e-mail kokubo@ However such a radical scavenging ability has not been well investigated systematically for functionalized fullerenes and the development of more efficient and easily accessible fullerene antioxidant derivatives has become an urgent requirement. In this article we first report that the introduction of pinup oxygen on C60 such as that