tailieunhanh - Báo cáo sinh học: " An immunocompromised BALB/c mouse model for respiratory syncytial virus infection"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: An immunocompromised BALB/c mouse model for respiratory syncytial virus infection | Virology Journal BioMed Central Research Open Access An immunocompromised BALB c mouse model for respiratory syncytial virus infection Xiaoyuan Kong1 Gary R Hellermann1 Geoff Patton1 Mukesh Kumar1 Aruna Behera1 Timothy S Randall1 Jian Zhang1 Richard F Lockey2 and Shyam S Mohapatra 1 2 Address Department of Internal Medicine Division of Allergy and Immunology Joy McCann Culverhouse Airway Disease Research Center University of South Florida College of Medicine USA and 2James A. Haley VA Hospital Tampa FL USA Email Xiaoyuan Kong - xkong@ Gary R Hellermann - ghellerm@ Geoff Patton - gpatton@ Mukesh Kumar - mkumar@ Aruna Behera - abehera@ Timothy S Randall - trandall@ Jian Zhang - jzhang@ Richard F Lockey - rlockey@ Shyam S Mohapatra - smohapat@ Corresponding author Published 8 February 2005 Received 6 December 2004 Accepted 8 February 2005 Virology Journal 2005 2 3 doi 1743-422X-2-3 This article is available from http content 2 1 3 2005 Kong et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Respiratory syncytial virus RSV infection causes bronchiolitis in infants and children which can be fatal especially in immunocompromised patients. The BALB c mouse currently used as a model for studying RSV immunopathology is semi-permissive to the virus. A mouse model that more closely mimics human RSV infection is needed. Since immunocompromised conditions increase risk of RSV infection the possibility of enhancing RSV infection in the BALB c mouse by pretreatment with cyclophosphamide was examined in this study. BALB c mice were treated with cyclophosphamide CYP and five days later they were