tailieunhanh - Báo cáo sinh học: " Introducing the Neurosciences Section of the Journal of Translational Medicine"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Introducing the Neurosciences Section of the Journal of Translational Medicine | Alguacil Journal of Translational Medicine 2011 9 117 http content 9 1 117 JOURNAL OF TRANSLATIONAL MEDICINE EDITORIAL Open Access Introducing the Neurosciences Section of the Journal of Translational Medicine Luis F Alguacil We must seriously think about proceeding further than looking for cures just for rodents . These ironic words were recently pronounced in a public forum by a medical doctor devoted to basic research who decided to move from experimentation in rat arteries to human vessels in her search for new targets for cardiovascular diseases. Scientists dealing with basic neuropsychiatric research must seriously examine this question and another one even more critical are we looking for cures for diseases in biological systems not willing to suffer them in nature In other words can we consider spontaneous dementia anorexia nervosa addiction or schizophrenia specific human diseases If so. is it intelligent trying to progress in the knowledge of these pathologies on the b asis of home-made artificial animal models Must we persist on this way or center exclusively on human experimentation The bench to bedside two-way travel is always problematic but it appears especially difficult when dealing with neuropsychiatric disorders where psychosocial variables seem to play an essential role both in the emergence and maintenance of the problem. This fact extremely complicates laboratory modeling. It is clear that the fast development of the neurosciences along the XX century has led to important medical progress enabling therapists to use modern advanced tools . rationale-based designed drugs instead of serendipitybased old remedies . However a significant gap still persists between basic science and medical applications for the patients in part due to the shortage sometimes absence of preclinical models with enough face construct and predictive validity. This may explain why we keep unable to find ways to defeat old classical .