tailieunhanh - Báo cáo hóa học: " Cell Creeping and Controlled Migration by Magnetic Carbon Nanotubes"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Cell Creeping and Controlled Migration by Magnetic Carbon Nanotubes | Nanoscale Res Lett 2010 5 257-262 DOI s11671-009-9463-y NANO IDEAS Cell Creeping and Controlled Migration by Magnetic Carbon Nanotubes V. Raffa O. Vittorio G. Ciofani V. Pensabene A. Cuschieri Received 28 March 2009 Accepted 5 October 2009 Published online 27 October 2009 to the authors 2009 Abstract Carbon nanotubes CNTs are tubular nanostructures that exhibit magnetic properties due to the metal catalyst impurities entrapped at their extremities during fabrication. When mammalian cells are cultured in a CNT-containing medium the nanotubes interact with the cells as a result of which on exposure to a magnetic field they are able to move cells towards the magnetic source. In the present paper we report on a model that describes the dynamics of this mammalian cell movement in a magnetic field consequent on CNT attachment. The model is based on Bell s theory of unbinding dynamics of receptor-ligand bonds modified and validated by experimental data of the movement dynamics of mammalian cells cultured with nanotubes and exposed to a magnetic field generated by a permanent magnet in the vicinity of the cell culture wells. We demonstrate that when the applied magnetic force is below a critical value about Fc 10-11 N the cell creeps very slowly on the culture dish at a very low velocity 10-20 nm s but becomes detached from the substrate when this critical magnetic force is exceeded and then move towards the magnetic source. Keywords Cell creeping and migration Carbon nanotubes Magnetism V. Raffa El O. Vittorio A. Cuschieri Medical Science Lab Scuola Superiore Sant Anna Piazza Martiri della Liberta 33 56127 Pisa Italy e-mail G. Ciofani V. Pensabene CRIM Lab Scuola Superiore Sant Anna Viale R. Piaggio 34 56025 Pontedera PI Italy V. Pensabene IIT Italian Institute of Technology 16125 Genoa Italy Introduction Carbon nanotubes CNTs 1 are molecular-scale tubes of graphite carbon with unique properties including extreme strength electric properties

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