tailieunhanh - Báo cáo hóa học: " The Reflux Disease Questionnaire: a measure for assessment of treatment response in clinical trials"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The Reflux Disease Questionnaire: a measure for assessment of treatment response in clinical trials | BioMed Central Health and Quality of Life Outcomes Research The Reflux Disease Questionnaire a measure for assessment of treatment response in clinical trials Michael Shaw1 John Dent 2 Timothy Beebe3 Ola Junghard4 Ingela Wiklund4 Tore Lind4 and Folke Johnsson5 Address 1Park Nicollet Clinic and University of Minnesota Medical School Minneapolis MN 55416-2699 USA 2Department of Gastroenterology and Hepatology Royal Adelaide Hospital Adelaide SA 5000 Australia 3Mayo Clinic College of Medicine Rochester MN 55905 USA 4AstraZeneca R D SE-431 83 Mõlndal Sweden and 5University of Lund SE-221 00 Lund Sweden Email Michael Shaw - shawmj@ John Dent - Timothy Beebe - Ola Junghard - Ingela Wiklund - Tore Lind - Folke Johnsson - Corresponding author Open Access Published 30 April 2008 Received 17 September 2007 Health and Quality of Life Outcomes 2008 6 31 doi 1477-7525-6-31 Accepted 30 April 2008 This article is available from http content 6 1 3 1 2008 Shaw et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Critical needs for treatment trials in gastroesophageal reflux disease GERD include assessing response to treatment evaluating symptom severity and translation of symptom questionnaires into multiple languages. We evaluated the previously validated Reflux Disease Questionnaire RDQ for internal consistency reliability responsiveness to change during treatment and the concordance between RDQ and specialty physician assessment of symptom severity .