tailieunhanh - Báo cáo khoa học: The IjBa gene is a peroxisome proliferator-activated receptor cardiac target gene

The purpose of this study was to provide a better understanding of the regula-tory role of the nuclear steroid receptor on the nuclear factor of kappa light polypeptide gene enhancer in B cells (NFjB) in mouse heart. NFjB regulates many nuclear genes and has been associated with many human cardiac dis-eases. | ỊFEBS Journal The Ik Ba gene is a peroxisome proliferator-activated receptor cardiac target gene Norman E. Buroker1 2 Julia Barboza3 and Jie-Yu Huang2 1 Department of Cardiology Seattle Children s Hospital WA USA 2 Department of Pediatrics University of Washington Schoolof Medicine Seattle WA USA 3 Department of Immunology Seattle Children s Hospital WA USA Keywords cardiac metabolism nuclear factor of kappa light polypeptide gene enhancer in B cells nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha gene peroxisomalproliferator response elements peroxisome proliferator-activated receptors Correspondence N. E. Buroker Department of Cardiology Seattle Children s Hospital Seattle WA 98101 and Department of Pediatrics University of Washington School of Medicine Seattle WA 98195 USA Fax 1 206 616 0471 Tel 1 206 616 0472 E-mail nburoker@ Received 6 January 2009 revised 10 March 2009 Accepted 6 April 2009 doi The purpose of this study was to provide a better understanding of the regulatory role of the nuclear steroid receptor on the nuclear factor of kappa light polypeptide gene enhancer in B cells NFkB in mouse heart. NFkB regulates many nuclear genes and has been associated with many human cardiac diseases. NFkB s protein regulator gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha gene IkBò was found in this study to be regulated by peroxisome proliferator-activated receptors PPARs . PPARs retinoid X receptors RXRs and thyroid hormone receptors THRs are members of the nuclear receptor superfamily which consists of a large number of transcription factors whose activities are regulated by their cognate ligands. These steroid hormone receptors are important regulators of gene expression and differentiation in the heart. These receptors form homo- RXR ThR and hetero- PPAR-RXR RXR-THR dimers that bind DNA at various response elements PPAR RXR and THR in the