tailieunhanh - Báo cáo hóa học: " Research Article Spectral Preprocessing for Clustering Time-Series Gene Expressions"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Research Article Spectral Preprocessing for Clustering Time-Series Gene Expressions | Hindawi Publishing Corporation EURASIP Journal on Bioinformatics and Systems Biology Volume 2009 Article ID 713248 10 pages doi 2009 713248 Research Article Spectral Preprocessing for Clustering Time-Series Gene Expressions Wentao Zhao 1 Erchin Serpedin EURASIP Member 1 and Edward R. Dougherty2 1 Electrical and Computer Engineering Department Texas A M University College Station TX 77843 USA 2 Translational Genomics Research Institute 400 North Fifth Street Suite 1600 Phoenix AZ 85004 USA Correspondence should be addressed to Erchin Serpedin serpedin@ Received 31 July 2008 Accepted 19 January 2009 Recommended by Yufei Huang Based on gene expression profiles genes can be partitioned into clusters which might be associated with biological processes or functions for example cell cycle circadian rhythm and so forth. This paper proposes a novel clustering preprocessing strategy which combines clustering with spectral estimation techniques so that the time information present in time series gene expressions is fully exploited. By comparing the clustering results with a set of biologically annotated yeast cell-cycle genes the proposed clustering strategy is corroborated to yield significantly different clusters from those created by the traditional expression-based schemes. The proposed technique is especially helpful in grouping genes participating in time-regulated processes. Copyright 2009 Wentao Zhao et al. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. 1. Introduction A cell is the basic unit of life and each cell contains instructions necessary for its proper functioning. These instructions are encoded in the form of DNAs that are replicated and transmitted to its progeny when the cell divides. mRNAs are middle products in this process. They are transcribed from DNA segments genes and