tailieunhanh - Báo cáo hóa học: " Research Article Towards Systems Biology of Heterosis: A Hypothesis about Molecular Network Structure "

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Research Article Towards Systems Biology of Heterosis: A Hypothesis about Molecular Network Structure | Hindawi Publishing Corporation EURASIP Journal on Bioinformatics and Systems Biology Volume 2009 Article ID 147157 12 pages doi 2009 147157 Research Article Towards Systems Biology of Heterosis A Hypothesis about Molecular Network Structure Applied for the Arabidopsis Metabolome Sandra Andorf 1 Tanja Gartner 2 Matthias Steinfath 2 Hanna Witucka-Wall 3 Thomas Altmann 3 and Dirk Repsilber1 1 Bioinformatics and Biomathematics Group Genetics and Biometry Unit Research Institute for the Biology of Farm Animals FBN Wilhelm-Stahl Allee 2 18196 Dummerstorf Germany 2 Institute for Biochemistry and Biology University of Potsdam Karl-Liebknecht-Str. 24-25 14476 Potsdam-Golm Germany 3 Institute for Genetics University of Potsdam Karl-Liebknecht-Str. 24-25 14476 Potsdam-Golm Germany Correspondence should be addressed to Dirk Repsilber Received 30 May 2008 Revised 18 July 2008 Accepted 4 August 2008 Recommended by J. Selbig We propose a network structure-based model for heterosis and investigate it relying on metabolite profiles from Arabidopsis. A simple feed-forward two-layer network model the Steinbuch matrix is used in our conceptual approach. It allows for directly relating structural network properties with biological function. Interpreting heterosis as increased adaptability our model predicts that the biological networks involved show increasing connectivity of regulatory interactions. A detailed analysis of metabolite profile data reveals that the increasing-connectivity prediction is true for graphical Gaussian models in our data from early development. This mirrors properties of observed heterotic Arabidopsis phenotypes. Furthermore the model predicts a limit for increasing hybrid vigor with increasing heterozygosity a known phenomenon in the literature. Copyright 2009 Sandra Andorf et al. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use distribution and reproduction in