tailieunhanh - Báo cáo hóa học: " A Novel Docetaxel-Loaded Poly (e-Caprolactone)/Pluronic F68 Nanoparticle Overcoming Multidrug Resistance for Breast Cancer Treatment"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: A Novel Docetaxel-Loaded Poly (e-Caprolactone)/Pluronic F68 Nanoparticle Overcoming Multidrug Resistance for Breast Cancer Treatment | Nanoscale Res Lett 2009 4 1530-1539 DOI S11671-009-9431-6 NANO EXPRESS A Novel Docetaxel-Loaded Poly s-Caprolactone ZPluronic F68 Nanoparticle Overcoming Multidrug Resistance for Breast Cancer Treatment Lin Mei Yangqing Zhang Yi Zheng Ge Tian Cunxian Song Dongye Yang Hongli Chen Hongfan Sun Yan Tian Kexin Liu Zhen Li Laiqiang Huang Received 12 June 2009 Accepted 1 September 2009 Published online 16 September 2009 to the authors 2009 Abstract Multidrug resistance MDR in tumor cells is a significant obstacle to the success of chemotherapy in many cancers. The purpose of this research is to test the possibility of docetaxel-loaded poly s-caprolactone Plu-ronic F68 PCL Pluronic F68 nanoparticles to overcome MDR in docetaxel-resistance human breast cancer cell line. Docetaxel-loaded nanoparticles were prepared by modified solvent displacement method using commercial PCL and self-synthesized PCL Pluronic F68 respectively. PCL Pluronic F68 nanoparticles were found to be of spherical L. Mei Y. Zhang Y. Zheng D. Yang L. Huang The Shenzhen Key Lab of Gene and Antibody Therapy Center for Biotech and Bio-Medicine and Division of Life Sciences Graduate School at Shenzhen Tsinghua University L308 Tsinghua Campus Xili University Town 518055 Shenzhen Guangdong China e-mail L. Huang e-mail huanglq@ L. Mei G. Tian Y. Tian K. Liu Z. Li College of Pharmacy Dalian Medical University 116027 Dalian Liaoning China C. Song H. Sun Institute of Biomedical Engineering Peking Union Medical College Chinese Academy of Medical Sciences The Tianjin Key Laboratory of Biomaterial Research 300192 Tianjin China D. Yang Department of Gastroenterology Xiangya Second Hospital Central South University 410011 Changsha China H. Chen Department of Life Science and Technology Xinxiang Medical University 453003 Xinxiang China shape with a rough and porous surface. The nanoparticles had an average size of around 200 nm with a narrow size distribution. The in